This refers to spinal cord damage involving the dorsal column, corticospinal tract, and spinothalamic tract unilaterally (hemisection). This causes weakness, Babinski sign, and loss of vibration and proprioception ipsilateral to the lesion, and loss of pain and temperature sensation on the contralateral side (2-3 segments below the lesion).

The most common causes of this syndrome are trauma (knife or bullet wound) and demyelination. Less common are tumors, herniation, and infection.